Best nootropic Aniracetam powder | Realnootropic

CAS Number 72432–10–1

Chemical and physical data

Formula C12H13NO3

Molar mass 219.237 g/mol g·mol−1

Aniracetam may sharpen focus and memory, reduce depression and anxiety, and even improve sleep. Its moderate price, low incidence of side effects, and widespread non-prescription availability make it a favorite among nootropic users.

What Is Aniracetam?

Aniracetam is a potent, fast-acting nootropic supplement that many consider a powerful cognitive enhancer and mood booster.

Discovered in the 1970s by Swiss pharmaceutical company Hoffman-LaRoche.

Aniracetam is an analog of piracetam, the first synthetic nootropic, and was originally developed as a more potent piracetam alternative.

Aniracetam is part of the racetam family of nootropics, a group of synthetic compounds that are similar in both chemical structure and mechanisms of action.

Like other racetams, aniracetam works primarily by modulating the production and release of neurotransmitters and other brain chemicals.

Benefits and Effects of Aniracetam

Though there have been relatively few human studies on aniracetam, it has been extensively researched for decades, and a substantial body of animal studies appear to support its efficacy as a nootropic. Aniracetam has several documented benefits and effects.

Enhanced Memory and Learning Capacity

Aniracetam’s reputation as a memory enhancer is backed up by research that indicates that it can improve functional memory and even reverse memory impairment.‍

In a study involving healthy human subjects, aniracetam was found to selectively improve various aspects of memory, including visual recognition, motor performance, and general intellectual functioning.‍

The means by which aniracetam enhances memory was investigated in animal studies which found that it positively impacts the pharmacological profile associated with learning and memory by elevating levels of acetylcholine, serotonin, glutamate, and dopamine in the brain.

Increased Focus and Concentration

Aniracetam is considered by many users to be one of the best nootropics for improving focus and concentration.‍

Though no human studies have centered on this aspect of the compound, its well-documented effects on acetylcholine, dopamine, and other important neurotransmitters strongly support this hypothesis.‍

Aniracetam also acts as an ampakine in stimulating the glutamate receptors that are involved in memory encoding and neuroplasticity, both of which are associated with focus and concentration.

Anxiety Reduction

One of aniracetam’s most important characteristics is its potential as an anxiolytic, or anxiety reducer.

Studies showed that aniracetam effectively reduced measures of anxiety and increased social interaction in rats, possibly by a combination of dopaminergic and serotonergic actions.‍

It is widely believed that the increased serotonin and dopamine that reduced anxiety in rats may have the same effect on people, and many users report decreased anxiety when taking aniracetam.

Anti-Depressant Properties

Aniracetam also proved to be an effective anti-depressant, significantly diminishing stress-induced immobility and brain dysfunction associated with aging.

Japanese researchers investigating the use of aniracetam for treating patients with post-stroke depression indicated that the positive anti-depression effects were notably more pronounced in aged rats than in young ones, but whether that finding holds true for humans is not clear.

Aniracetam’s anti-depression capability is believed to be primarily due to increased dopaminergic transmission and acetylcholine receptor stimulation.

Dementia Treatment

Clinical trials have shown aniracetam to be a safe and effective treatment for mild to severe dementia, enhancing mood and improving function for at least 12 months.

In one of the few human studies on aniracetam, a total of 276 cognitive disorder patients with a mean age of 71 years were divided into four groups to test the effectiveness of aniracetam as a dementia treatment, alone or in combination with other drugs. Over a period of 12 months, patients treated with aniracetam demonstrated significantly better cognitive performance, improved function, and enhanced mood and emotional stability.

How It Works

Aniracetam’s exact mechanisms of action are not completely understood, but decades of research give a good indication of how it impacts mood and cognition by its actions within the brain and central nervous system.

Aniracetam is a fat-soluble compound that is metabolized in the liver and quickly absorbed and transported throughout the body. It is known to cross the blood-brain barrier very quickly, and

users frequently report feeling its effects in as little as 30 minutes.‍

In the brain, aniracetam upregulates the production of several crucial neurotransmitters, all of which are associated with mood, memory, and cognition:

Acetylcholine — Aniracetam may improve general cognition by enhancing activity throughout the acetylcholine system, which plays a pivotal role in memory, attention span, learning speed and other cognitive processes. Studies suggest that it works by binding to acetylcholine receptors, inhibiting receptor desensitization and promoting the synaptic release of acetylcholine.‍ Dopamine and Serotonin — Aniracetam has been shown to increase levels of dopamine and serotonin in the brain, which in turn is known to relieve depression, boost energy, and lessen anxiety. By binding to dopamine and serotonin receptors, aniracetam inhibits the breakdown of these important neurotransmitters and restores optimum levels of both, making it an effective mood enhancer and anxiolytic.‍

Glutamate Transmission — Aniracetam may be uniquely effective at improving memory and information storage because of the way it enhances the transmission of glutamate, the neurotransmitter that plays the primary role in neural activation. By binding to and stimulating the AMPA and kainate receptors, glutamate receptors strongly associated with information storage and the creation of new memories, aniracetam may improve neuroplasticity in general and long-term potentiation in particular.‍

Dosage

While individual requirements vary, a daily dosage of 750–1500 mg is typically accepted as both safe and effective, though doses of up to 3000 mg daily have been documented as well-tolerated.

One human study involving individuals with senile cognitive disorders reported benefits over placebo at 1500 mg/day.‍

It is always recommended to start with the minimum effective dose and gradually increase as necessary.

Like most nootropics in the racetam family, the effects of aniracetam may diminish if too much is present in the system, so dosage should be monitored closely.

Because of its relatively brief half-life of one to three hours, dosage may have to be repeated at intervals to maintain effects.

Originally published at https://realnootropic.com.